SPRAVATO® (Esketamine) Treatment

A New Option for Treatment-Resistant Depression

At Journey Psychiatry & Behavioral Health, proudly serving Trinity and the greater Tampa Bay area, we offer SPRAVATO® (esketamine) nasal spray for adults struggling with depression that hasn’t improved with traditional treatments.

If you’re feeling stuck, exhausted, or discouraged after trying multiple antidepressants, you’re not alone, and there are new options. SPRAVATO® offers a different approach and renewed hope for many patients.

This treatment is available for both new and existing patients following a comprehensive evaluation.

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  • SPRAVATO® is an FDA‑approved nasal spray derived from ketamine and used in combination with an oral antidepressant. Unlike daily medications that work gradually, SPRAVATO® targets the brain’s glutamate system, which plays a key role in mood, learning, and neuroplasticity.

    Many patients report:

    • Rapid improvement in depressive symptoms

    • Relief from emotional numbness or hopelessness

    • Improved ability to engage in therapy and daily life

  • SPRAVATO® helps the brain form new neural connections, which may restore communication between areas involved in mood regulation.

    During treatment:

    • The medication is self‑administered under medical supervision

    • Sessions last about 2 hours for monitoring

    • Temporary effects such as dissociation, dizziness, or sleepiness may occur

    Between treatments:

    • Patients often notice improved mood, clarity, and emotional flexibility

    • Benefits may build over time with a structured treatment plan

    1. Comprehensive Evaluation
      A Journey Psychiatry provider will determine if SPRAVATO® is appropriate for you.

    2. Treatment Sessions

      • Administered in‑office only

      • Comfortable, calm setting

      • Continuous monitoring by trained clinical staff

    3. Post‑Treatment Care

      • You’ll need a ride home after each session

      • Ongoing medication management and therapy coordination

  • SPRAVATO® may be an option for you if:

    • You’ve tried two or more antidepressant medications without adequate relief

    • You continue to experience persistent or severe depressive symptoms

    • You are a new patient seeking advanced treatment options or an existing patient who hasn’t responded well to current medications

    If you’re an existing Journey Psychiatry patient and feel that your current treatment isn’t working, simply let your provider know you’d like to discuss SPRAVATO® as a potential next step.

    A full evaluation is required to determine eligibility and ensure this treatment is appropriate for you.

  • SPRAVATO® is only available through the FDA’s REMS program to ensure safety.

    At Journey Psychiatry, we prioritize:

    • Medical oversight by psychiatric providers

    • Blood pressure and symptom monitoring

    • Trauma‑informed, patient‑centered care

  • Many insurance plans cover SPRAVATO® for approved indications.

    Our team will:

    • Verify benefits

    • Assist with prior authorizations

    • Discuss out‑of‑pocket costs upfront

  • Journey Psychiatry is unique in our team-based, collaborative approach to SPRAVATO® treatment.

    What sets us apart:

    • Experienced psychiatric providers and dedicated SPRAVATO® clinical staff

    • Our private SPRAVATO® treatment rooms are intentionally designed to enhance comfort, privacy, and emotional safety—supporting a more meaningful and restorative experience.

    • Optional SPRAVATO® therapy sessions offered in conjunction with treatment

    By combining medication treatment with guided therapeutic (counseling) support, we help patients:

    • Process their experience safely

    • With coordinated therapy, patients are often able to connect more deeply with their emotions & experiences, creating space for insight, healing, and lasting change.

    • Feel supported by a coordinated care team

    This integrated approach is designed to optimize outcomes and support long-term healing—not just symptom relief.

  • If depression has felt overwhelming or resistant to treatment, SPRAVATO® may offer a new path forward.

    • New patients: Reach out to schedule an evaluation with our team

    • Existing patients: Let your provider know you’d like to explore SPRAVATO® as an option

    You’re also welcome to contact our SPRAVATO® Coordinator, who can guide you through the process, answer questions, and help you feel confident about next steps.

    📞 Call us or request an appointment today to begin a hopeful, supported journey toward healing.

SPRAVATO® is a registered trademark of Janssen Pharmaceuticals. This page is for informational purposes only and does not replace medical advice.